These seeds contain non-laxative compounds such as rhamnol, linoleic acid, myristic acid, and syringic acid, as well as starch and fat. Compared to other weight loss supplements, these ingredients have an average of 7% to 25% protein and 13% to 57% oil. While cascara is generally well tolerated, it should not be used by pregnant or nursing women or children younger than 12. It should not be taken for prolonged periods and should be avoided in cases of inflammatory conditions of the colon. If you are taking a medication, shell should not be taken. However, if you are taking any of these medications, it may interact with the supplement. If you are taking a prescription drug, you should also consult your doctor before using this supplement. The benefits of are not well-known, however, because of a lack of scientific evidence. Although it is safe for short-term use, it should be avoided if you have a history of allergies or chronic medical conditions.